The iSWAB-Microbiome (MB) is a non-toxic stabilizing technology that enables inactivation of bacteria, fungi, spores, and viruses, allows ambient collection and transport of various biosamples, and maintains the status quo at the time of collection. iSWAB-MB provides a representative snapshot of the microbial community that remains unchanged from collection to processing of oral, gut/fecal, skin, vaginal, and soil samples.